Innovation and healthcare are closely connected as new drug, equipment, disease treatment and service delivery are developed and adopted to bring value to stakeholders. Still, in the last decades, there is a concern about the constant increase of healthcare costs, being one of the main factors the adoption of the same technologies that were supposed to improve patient conditions. Being the innovation inaccessible, it is not bringing real value for patients. On the other hand, mobile technologies are allowing the creation of service platforms that link both technology and service innovation to provide high availability and lower costs in primary care. Can this trend disrupt the health care industry? Innovations on health care must always follow increased costs and lower access? In order to answer these questions, it was advanced a service innovation definition, which was articulated with disruptive innovation and innovation system insights. Thenceforth, it was made a revision of the literature of the last 10 years on healthcare mobile innovation to identify what the technology tendencies are. Startup companies’ entrepreneurs were interviewed and the information was submitted to the proposed theoretical framework. It is concluded that health care has the potential to be disrupted by mobile technologies, once they bring innovative, low cost solutions to patients, physicians and other stakeholders. However, the startup companies’ level of maturity can be a limitation for a more conclusive argument.